Description: Concerted efforts to deepen understanding of RNA modifications and their role in living systems hold the potential to advance human health, improve crop yields, and address other pressing societal challenges. RNA, which carries the information encoded by DNA to the places where it is needed, is amazingly diverse and dynamic. RNA is processed and modified through natural biological pathways, giving rise to hundreds, in some cases thousands, of distinct RNA molecules for each gene, thereby diversifying genetic information. RNA modifications are known to be pivotal players in nearly all biological processes, and their dysregulation has been implicated in a wide range of human diseases and disorders. Yet, our knowledge of RNA modifications remains incomplete, hindered by current technological limitations. Existing methods cannot discover all RNA modifications, let alone comprehensively sequence them on every RNA molecule. Nonetheless, what is known about RNA modifications has already been leveraged in the development of vaccines that helped saved millions of lives worldwide during the COVID-19 pandemic. RNA modifications also have applications beyond health, for example, enhancing agricultural productivity.
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Location: Madison, Wisconsin
End Time: 2025-01-09T19:13:47.000Z
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Subject Area: Science, Medical
Book Title: Charting a Future for Sequencing RNA and Its Modifications
Publication Name: Charting a Future for Sequencing RNA and Its Modifications: A New
Publisher: National Academies Press
Item Length: 10 in
Subject: Life Sciences / Genetics & Genomics, Genetics, Research
Publication Year: 2024
Type: Textbook
Format: Trade Paperback
Language: English
ISBN-13: 9780309706957
Author: Board on Life Sciences, Division on Earth and Life Studies, Engineering National Academies of Sciences and Medicine, Board on Health Sciences Policy, Health and Medicine Division
Item Width: 7 in
Number of Pages: 248 Pages